![]() ![]() However, incidence of most hematologic malignancies needing HSCT increases with age, and number of elderly needing HSCT have also increased with the aging of the population. Given the high transplant-related morbidity and mortality, HSCT was initially restricted to younger patients and was not indicated in patients older than 55 years of age. ![]() Keywords: Dementia Treatment Survival Hematopoietic stem cell transplantation.Īllogeneic hematopoietic stem cell transplantation (HSCT) provides life-prolonging or curative therapy for critical hematologic disorders, but it is a highly aggressive and demanding therapy with a significant risk of mortality. With number of elderly needing HSCT is increasing, further work to establish treatment guidelines for the management of HSCT in people with dementia is needed. In multivariate analysis, dementia had significant impacts on OS (hazard risk = 2.539, 95% CI, 1.166−4.771, p = 0.017).Ĭonclusion: Our results indicated that patients diagnosed with dementia before HSCT have 2.539 times higher risk of mortality after transplantation than those not having dementia. Results: With median follow-up of 621 days for dementia group and 654 days for non-dementia group, 2 year-OS of dementia group was lower than that of non-dementia group (53.3% vs. Patients were followed from the day they received HSCT to the occurrence of death or the last follow-up day (December 31, 2018), whichever came first. Thereafter, among 2,666 participants without dementia, 93 patients were selected via propensity-matched score as non-dementia group. Remaining patients were divided into those who were and were not diagnosed with dementia before HSCT (dementia group: n = 31 no dementia: n = 2,666). Methods: Among 8,230 patients who underwent HSCT between 20, 5,533 patients younger than 50 years were first excluded. We aimed to investigate overall survival (OS) of patients with dementia after receiving HSCT. 24, 2021, 03:34 p.m.Abstract Objective: No previous study examined impact of dementia in the outcome of allogeneic hematopoietic stem cell transplantation (HSCT). Expert Alert: 3 reasons why more organ donors from diverse backgrounds are needed Aug.Sharing Mayo Clinic: "Divine design" gives multiple myeloma patient transplant, care at home Sept.Sharing Mayo Clinic: Diversity in bone marrow transplantation is gift of life for their mom Sept.Research into rare neurological disorder gives Lisa Miller a new lease on life Dec.Mayo Clinic, Carnegie Mellon University to collaborate on transplant innovation Feb.Transplant, new model of care give hope to Salvadoran mom after cancer diagnosis March 31, 2022, 12:17 p.m.Mayo Clinic Minute: Bone marrow donor diversity is needed July 13, 2022, 03:00 p.m.Expert alert: Five key medical advances related to bone marrow transplantation Oct.Mayo Clinic Q&A podcast: Advances in bone marrow transplant and cellular therapy Nov.Mayo Clinic Q&A podcast: Advancing treatments for acute myeloid leukemia Dec.You'll meet with your care team frequently to watch for side effects and to monitor your body's response to the transplant. Your stem cells will be infused into your bloodstream, where they will travel to your bone marrow and begin creating new blood cells.Īfter your autologous stem cell transplant, you'll remain under close medical care. Talk with your doctor about what you can expect from your treatment. The cancer treatments used during the conditioning process carry a risk of side effects. The treatments you undergo depend on your disease and your particular situation. During the conditioning process, you'll receive high doses of chemotherapy or radiation therapy - or sometimes both treatments - to kill your cancer cells. Undergoing high doses of cancer treatment (conditioning). A machine filters out the stem cells and the rest of your blood is returned to your body.Ī preservative is added to your stem cells and then they're frozen and stored for later use. For stem cell collection, a needle is inserted into a vein in your arm to draw out your blood. You'll receive medications that cause your stem cells to increase in number and to move out of your bone marrow and into your blood, where they can be easily collected.įiltering stem cells from your blood. Taking medications to increase the number of stem cells in your blood.Undergoing an autologous stem cell transplant involves: An autologous stem cell transplant helps to replace the damaged bone marrow.Īn autologous stem cell transplant is most often used to treat: These treatments are likely to damage the bone marrow. ![]() Autologous stem cell transplants are typically used in people who need to undergo high doses of chemotherapy and radiation to cure their diseases. ![]()
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